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KDM5B Promotes Breast Cancer Cell Proliferation and Migration via AMPK-mediated Lipid Metabolism Reprogramming

KDM5B Promotes Breast Cancer Cell Proliferation and Migration via AMPK-mediated Lipid Metabolism Reprogramming

Zhong-Guo Zhang, Hong-Sheng Zhang, Hong-Liang Sun, Hui-Yun Liu, Min-Yao Liu, Zhen Zhou

Exp Cell Res. 2019 Jun 15;379(2):182-190.

PMID: 30978340

Abstract:

Lysine demethylase 5B (KDM5B) is up-regulated in many cancers, including breast cancer. However, the underlying metabolic mechanisms of KDM5B on breast cancer progression are poorly understood. Here, we showed that KDM5B expression positively correlates with metastasis in breast cancer. Cell functional analyses were demonstrated that KDM5B knockdown and KDM5B inhibitor AS-8351 inhibited breast cancer cell proliferation and migration. Furthermore, we reported that KDM5B knockdown and AS-8351 reversed epithelial-mesenchymal transition (EMT) and decreased the protein levels of fatty acid synthase (FASN) and ATP citrate lyase (ACLY) in MCF-7 and MDA-MB-231 cells. Interestingly, we found that activation of AMP-activated protein kinase (AMPK) signaling pathway is involved in KDM5B-mediated EMT and lipid metabolism reprogramming in breast cancer cells. As a result, silencing of KDM5B-induced activation of AMPK signaling pathway inhibited breast cancer cell proliferation and migration. Taken together, our findings indicated that KDM5B was a novel regulator of lipid metabolism reprogramming, and it was suggested a new strategy to treat breast cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP796429	AS8351		796-42-9	Price

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