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Ketone Bodies as Signaling Metabolites

Ketone Bodies as Signaling Metabolites

John C Newman, Eric Verdin

Trends Endocrinol Metab. 2014 Jan;25(1):42-52.

PMID: 24140022

Abstract:

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, and gene expression via chromatin modifications. We review the regulation and functions of ketone bodies, the relationship between ketone bodies and calorie restriction, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241371	Z-Leu-Leu-Leu-fluoromethyl ketone			Price

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