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Ketotifen Controlled Release From Cellulose Acetate Propionate and Cellulose Acetate Butyrate Membranes

Ketotifen Controlled Release From Cellulose Acetate Propionate and Cellulose Acetate Butyrate Membranes

Manuela C C M Sobral, Abilio J F N Sobral, J T Guthrie, M H Gil

J Mater Sci Mater Med. 2008 Feb;19(2):677-82.

PMID: 17619990

Abstract:

Ketotifen was immobilised in cellulose acetate propionate (CAP) membranes and in cellulose acetate butyrate (CAB) membranes. The characteristics of each system were evaluated under a range of experimental conditions. The topography and uniformity of the membranes was assessed using scanning electron microscopy. The release characteristics associated with Ketotifen were monitored spectrophotometrically. The swelling capacity of the membranes was evaluated and attributed to the combined effects of diffusion and of complex dissociation, during swelling. The materials produced were able to provide controlled release of Ketotifen due to their controlled swelling behaviour and adequate release properties. The results showed that the release of Ketotifen from the CAB membranes is higher but the release from the CAP membranes is more uniform.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004391	Cellulose acetate propionate		9004-39-1	Price

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