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Kinetics of Drug Decomposition. Part 62. Kinetics of Penicillin G Potassium Salt (PGP) Thermal Degradation in Solid Phase

Kinetics of Drug Decomposition. Part 62. Kinetics of Penicillin G Potassium Salt (PGP) Thermal Degradation in Solid Phase

E Pawełczyk, Z Płotkowiak, K Knitter, B Kozakiewicz-Wegner

Pol J Pharmacol Pharm. Jan-Feb 1980;32(1):55-62.

PMID: 7454612

Abstract:

The kinetics of degradation of penicillin G K salt (PGP) in solid phase in the temperature range 70-140 degrees C were investigated. The obtained sigmoidal curves were interpreted in terms of the Prout-Tompkins kinetics. The appropriate mathematical equations were derived for the induction and acceleration periods which enable to calculate the degradation half-time, t0.1 value and the induction time (t'). The Arrhenius plot shows the isokinetic point where the rates of reaction for both periods are identical.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP113984-A	Penicillin G potassium salt		113-98-4	Price

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