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Kinetics of Fluphenazine After Fluphenazine Dihydrochloride, Enanthate and Decanoate Administration to Man

Kinetics of Fluphenazine After Fluphenazine Dihydrochloride, Enanthate and Decanoate Administration to Man

S H Curry, R Whelpton, P J de Schepper, S Vranckx, A A Schiff

Br J Clin Pharmacol. 1979 Apr;7(4):325-31.

PMID: 444352

Abstract:

1 Fluphenazine (1,2-ethanol 14C) was administered to seven human subjects as the dihydrochloride and as the enanthate and decanoate esters. 2 The subjects had previously been treated with fluphenazine injections for at least 6 months. 3 Fluphenazine was separated from its radioactive metabolites by selective solvent extraction. Plasma concentrations were measured for up to 21 days after dosing. 4 The preparations showed differences in peak concentrations, times of the peaks and half-times of the elimination phase. The longest half-times occurred with the decanoate and the shortest with the dihydrochloride. 5 It is postulated that the differences in kinetics relate principally to the release of the compound from the site of injection. 6 There was no evidence for presence of the esters in plasma, urine or faeces.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3105688	Fluphenazine enanthate dihydrochloride		3105-68-8	Price

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