Home
Resources
Publications
Kinetics of Nornicotine and Anabasine Nitrosation in Relation to N'-nitrosonornicotine Occurrence in Tobacco and to Tobacco-Induced Cancer

Kinetics of Nornicotine and Anabasine Nitrosation in Relation to N'-nitrosonornicotine Occurrence in Tobacco and to Tobacco-Induced Cancer

S S Mirvish, J Sams, S S Hecht

J Natl Cancer Inst. 1977 Oct;59(4):1211-3.

PMID: 561854

Abstract:

The kinetics of nornicotine and anabasine nitrosation, studied in aqueous solution, obeyed equations typical for the nitrosation of aliphatic secondary amines, with third-order stoichiometric rate constants of 1.15 (nornicotine) and 0.86 (anabasine) M-2 sec-1. The similarity of the two rate constants suggested that the nitrosonornicotine occurring in tobacco arises from nicotine rather than nornicotine, because tobacco contains anabasine but apparently does not contain nitrosoanabasine. The high rate constants suggested that in vivo nitrosation of these secondary amines may constitute a hazard to tobacco smokers and chewers, in addition to that presented by preformed nitrosonornicotine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5746861-A	(±)-Nornicotine solution		5746-86-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: