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l-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice

l-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice

Yan Li, Haiou Pan, Jin-Xin Liu, Tingting Li, Shengnan Liu, Wenli Shi, Chao Sun, Mingcong Fan, Lamei Xue, Yu Wang, Chenzhipeng Nie, Hui Zhang, Haifeng Qian, Hao Ying, Li Wang

J Agric Food Chem. 2019 Dec 4;67(48):13299-13306.

PMID: 31674784

Abstract:

l-Arabinose is a monosaccharide extracted from plants or fibers, which is known to have a variety of functional properties. In this study, we aim to investigate whether l-arabinose could inhibit colitis by modulating gut microbiota. l-Arabinose was administered in mice daily in a dextran sodium sulfate (DSS)-induced colitis model. The histological analysis, disease index, and the expression of inflammatory genes were measured. 16S-rRNA sequence analysis was performed to investigate gut microbiota. Intriguingly, we found that l-arabinose could repress DSS-induced colitis and inhibit p38-/p65-dependent inflammation activation. Besides that, our data revealed that l-arabinose-modulated DSS-induced gut microbiota were disturbed. Additionally, the perturbed gut microbiota was responsible for the suppressive effects of l-arabinose on DSS-induced colitis treated with antibiotics. Lastly, Caco-2 cells were used to confirm the protective effects of l-arabinose in colitis or inflammatory bowel disease. As expected, the protein expression levels in Caco-2 cells of pro-inflammatory genes, which were treated with l-arabinose and incubated with or without tumor necrosis factor alpha. Our work suggested that l-arabinose exerts anti-inflammation effects in DSS-induced colitis. These beneficial effects have correlations with the composition, diversity, and abundance of the gut microbiota regulated by l-arabinose. l-Arabinose could be a remarkable candidate as a functional food or novel therapeutic strategy for intestinal health.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5328370	Arabinose		5328-37-0	Price

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