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L-glutamine Protects Mouse Brain From Ischemic Injury via Up-Regulating Heat Shock Protein 70

L-glutamine Protects Mouse Brain From Ischemic Injury via Up-Regulating Heat Shock Protein 70

Long-Long Luo, Yong-Fang Li, Hui-Min Shan, Li-Ping Wang, Fang Yuan, Yuan-Yuan Ma, Wan-Lu Li, Ting-Ting He, Yu-Yang Wang, Mei-Jie Qu, Huai-Bin Liang, Zhi-Jun Zhang, Guo-Yuan Yang, Yao-Hui Tang, Yong-Ting Wang

CNS Neurosci Ther. 2019 Sep;25(9):1030-1041.

PMID: 31218845

Abstract:

Introduction:
L-glutamine is an antioxidant that plays a role in a variety of biochemical processes. Given that oxidative stress is a key component of stroke pathology, the potential of L-glutamine in the treatment of ischemic stroke is worth exploring.
Aims:
In this study, we investigated the effect and mechanisms of action of L-glutamine after cerebral ischemic injury.
Results:
L-glutamine reduced brain infarct volume and promoted neurobehavioral recovery in mice. L-glutamine administration increased the expression of heat-shock protein 70 (HSP70) in astrocytes and endothelial cells. Such effects were abolished by the coadministration of Apoptozole, an inhibitor of the ATPase activity of HSP70. L-glutamine also reduced oxidative stress and neuronal apoptosis, and increased the level of superoxide dismutase, glutathione, and brain-derived neurotrophic factor. Cotreatment with Apoptozole abolished these effects. Cell culture study further revealed that the conditioned medium from astrocytes cultured with L-glutamine reduced the apoptosis of neurons after oxygen-glucose deprivation.
Conclusion:
L-glutamine attenuated ischemic brain injury and promoted functional recovery via HSP70, suggesting its potential in ischemic stroke therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241047	Heat Shock Protein 25 from mouse			Price

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