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Lactobacillus Plantarum Lipoteichoic Acid Inhibits Biofilm Formation of Streptococcus Mutans

Lactobacillus Plantarum Lipoteichoic Acid Inhibits Biofilm Formation of Streptococcus Mutans

Ki Bum Ahn, Jung Eun Baik, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han

PLoS One. 2018 Feb 8;13(2):e0192694.

PMID: 29420616

Abstract:

Dental caries is a biofilm-dependent oral disease and Streptococcus mutans is the known primary etiologic agent of dental caries that initiates biofilm formation on tooth surfaces. Although some Lactobacillus strains inhibit biofilm formation of oral pathogenic bacteria, the molecular mechanisms by which lactobacilli inhibit bacterial biofilm formation are not clearly understood. In this study, we demonstrated that Lactobacillus plantarum lipoteichoic acid (Lp.LTA) inhibited the biofilm formation of S. mutans on polystyrene plates, hydroxyapatite discs, and dentin slices without affecting the bacterial growth. Lp.LTA interferes with sucrose decomposition of S. mutans required for the production of exopolysaccharide, which is a main component of biofilm. Lp.LTA also attenuated the biding of fluorescein isothiocyanate-conjugated dextran to S. mutans, which is known to have a high affinity to exopolysaccharide on S. mutans. Dealanylated Lp.LTA did not inhibit biofilm formation of S. mutans implying that D-alanine moieties in the Lp.LTA structure were crucial for inhibition. Collectively, these results suggest that Lp.LTA attenuates S. mutans biofilm formation and could be used to develop effective anticaries agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74849	Fluorescein isothiocyanate - Dextran 500000-Conjugate			Price

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