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Lactulose: Patient- And Dose-Dependent Prebiotic Properties in Humans

Lactulose: Patient- And Dose-Dependent Prebiotic Properties in Humans

Jakub Ruszkowski, Jacek M Witkowski

Anaerobe. 2019 Oct;59:100-106.

PMID: 31176002

Abstract:

Lactulose is a disaccharide used in clinical practice since 1957 and has since been tested in the treatment of many human disorders, including chronic constipation, hepatic encephalopathy, and chronic kidney disease. Its mode of action is based on the lactulose fermentation by intestinal microbiota. Based on in silico, in vitro and in vivo studies we comprehensively review here the impact of lactulose on human gut/fecal and vaginal microbiota composition and both fecal and blood metabolomes. However, both in vitro and in vivo studies summarized in this review have revealed that the effects of lactulose on human microbiota composition are both patient- and dose-dependent. This highlights the need of heterogeneity indication in clinical trials.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4618182-A	Lactulose		4618-18-2	Price

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