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Lambda Light Chain Non-crystalline Proximal Tubulopathy With IgD Lambda Myeloma

Lambda Light Chain Non-crystalline Proximal Tubulopathy With IgD Lambda Myeloma

Seiji Kishi, Fumiaki Obata, Hirokazu Miki, Motokazu Matsuura, Kenji Nishimura, Masanori Tamaki, Fumi Kishi, Taichi Murakami, Hideharu Abe, Kojiro Nagai, Masahiro Abe, Toshio Doi

Intern Med. 2018 Dec 15;57(24):3597-3602.

PMID: 30101939

Abstract:

Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42411684	Lambda Light Chains (Free) from human myeloma sera			Price

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