Lanolin

PMID: 30000902

Abstract:

Lanolin is a yellow fat obtained from sheep's wool. It has traditionally been used topically to treat sore, cracked nipples during breastfeeding. Highly purified modified lanolin (Lansinoh) has the pesticide and detergent residues removed and the natural free alcohols reduced to below 1.5% to improve safety and reduce the allergic potential.[1] However, it should be avoided in patients with a known allergy to wool.
Although lanolin appears to be effective for the prevention and treatment of nipple pain from breastfeeding,[2] studies, most of which used Lansinoh, have not found lanolin to be consistently different in efficacy from application of breastmilk, hydrogel dressings, peppermint gel, aloe vera or warm compresses.[3][4][5][6][7][8][9] A metaanalysis concluded that application of nothing or breastmilk may be superior to lanolin, but good studies are lacking.[10] One small nonblinded study found olive oil to be superior to lanolin for prevention of sore nipples,[11] and another small, single-blinded study found that lanolin application to painful nipples did not decrease nipple pain compared to usual care.[12] A study in women with nipple trauma and pain comparing application of lanolin after each feeding to application of breastmilk plus a nipple shell found that the breastmilk and shell were more effective than lanolin.[13] A randomized study comparing highly purified lanolin (Lansinoh) to expressed breastmilk in 180 mothers, found lanolin to be superior to breastmilk over a 7-day period in reducing pain and the nipple trauma score.[14]

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP8006540-A	Lanolin		8006-54-0	Price

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