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Latrunculin a Has a Strong Anticancer Effect in a Peritoneal Dissemination Model of Human Gastric Cancer in Mice

Latrunculin a Has a Strong Anticancer Effect in a Peritoneal Dissemination Model of Human Gastric Cancer in Mice

Hiroo Konishi, Shojiro Kikuchi, Toshiya Ochiai, Hisashi Ikoma, Takeshi Kubota, Daisuke Ichikawa, Hitoshi Fujiwara, Kazuma Okamoto, Chouhei Sakakura, Teruhisa Sonoyama, Yukihito Kokuba, Hiroyuki Sasaki, etc.

Anticancer Res. 2009 Jun;29(6):2091-7.

PMID: 19528469

Abstract:

Peritoneal dissemination of gastric cancer is a refractory disease. This paper focuses on the efficacy of actin-binding marine macrolide latrunculin A, which quickly inhibits actin polymerization and disrupts the function of the actin cytoskeleton. The effects of latrunculin A on cell viability in vitro were evaluated by treatment of MKN45 or NUGC-4 cell cultures. An in vitro viability assay demonstrated an anticancer effect of latrunculin A in a dose-dependent manner. Latrunculin A induced acute cell injury and programmed cell death through activating the caspase-3/7 pathway. In vivo, MKN45 or NUGC-4 cells were intraperitoneally inoculated into nude mice, as a model of peritoneal dissemination. Intraperitoneal (i.p.) injection of latrunculin A significantly improved survival rate in mice without any major side-effects. Data indicated that latrunculin A has strong anticancer effects, and it may be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in humans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76343936	Latrunculin A		76343-93-6	Price

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