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LC/MS/MS Determination and Pharmacokinetic Study of Iridoid Glycosides Monotropein and Deacetylasperulosidic Acid Isomers in Rat Plasma After Oral Administration of Morinda Officinalis Extract

LC/MS/MS Determination and Pharmacokinetic Study of Iridoid Glycosides Monotropein and Deacetylasperulosidic Acid Isomers in Rat Plasma After Oral Administration of Morinda Officinalis Extract

Chunmin Li, Jian Dong, Jingchang Tian, Zhipeng Deng, Xiujing Song

Biomed Chromatogr. 2016 Feb;30(2):163-8.

PMID: 26053360

Abstract:

Morinda officinalis is a famous traditional Chinese medicine containing iridoid glycoside compounds, such as monotropein and deacetylasperulosidic acid. The aim of the study was to develop a novel and sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of the two isomeric iridoid glycosides and then evaluate their pharmacokinetic properties in rats. Selected-reaction monitoring mode was employed for quantification of two analytes in rat plasma. The calibration curves were linear over their respective concentration range with correlation coefficient >0.995 for both analytes. Precision for monotropein and deacetylasperulosidic acid ranged from 2.5 to 11.9% relative standard deviation, and the accuracy of two analytes was -2.0-3.7 and -6.4-10.7% relative error, respectively. This method was successfully applied in pharmacokinetic study after oral administration of M. officinalis extract in rats. The results provided a basis for further research on the bioactivity of M. officinalis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14259553	Deacetylasperulosidic acid		14259-55-3	Price

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