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Leishmania Major: Antileishmanial Activity of Methylbenzethonium Chloride

J El-On, G Messer

Am J Trop Med Hyg. 1986 Nov;35(6):1110-6.

PMID: 3789266

Abstract:

Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 micrograms ml-1. MBCl at 2 micrograms ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1320441 Methylbenzethonium chloride Methylbenzethonium chloride 1320-44-1 Price
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