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Leojaponic Acids A and B, Two New Homologous Terpenoids, Isolated From Leonurus Japonicus

Leojaponic Acids A and B, Two New Homologous Terpenoids, Isolated From Leonurus Japonicus

Han-Kui Wu, Yan-Jun Mao, Shan-Shan Sun, Zhi-Yong Xu, Ya Ma, Jin-Xia Cao, He Qi, Zhi-Fu Wu, Gang Li, Wei-Hua Yang

Chin J Nat Med. 2016 Apr;14(4):303-307.

PMID: 27114319

Abstract:

The present study aimed at isolation and purification of the bioactive terpenoids from the herb of Leonurus japonicus by chromatographic separations such as silica gel, sephadex LH-20 and C18 reversed phase silica gel, as well as preparative HPLC. As a result, leojaponic acids A (1, C17H24O4) and B (2, C18H26O4), two homologous terpenoids, together with (-)-loliolide (3), 1-(3-ethylphenyl) ethane-1, 2-diol (4) and dibutyl phthalate (5), were isolated from the EtOH extract of L. japonicus. All the chemical structures of the isolates were elucidated on the basis of 1D and 2D NMR analyses. Compounds 1 and 2 were new terpenoids, and Compounds 3 and 4 were isolated and identified for the first time from this plant. In addition, the α-glucosidase and tyrosinase inhibitory activity of the new compounds were evaluated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LPLC81602	C18-Reversed phase silica gel			Price

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