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Leucosulfakinin, a Sulfated Insect Neuropeptide With Homology to Gastrin and Cholecystokinin

Leucosulfakinin, a Sulfated Insect Neuropeptide With Homology to Gastrin and Cholecystokinin

R J Nachman, G M Holman, W F Haddon, N Ling

Science. 1986 Oct 3;234(4772):71-3.

PMID: 3749893

Abstract:

A sulfated, myotropic neuropeptide termed leucosulfakinin (Glu-Gln-Phe-Glu-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2) was isolated from head extracts of the cockroach Leucophaea maderae. The peptide exhibits sequence homology with the hormonally active portion of the vertebrate hormones human gastrin II and cholecystokinin, suggesting that these peptides are evolutionarily related. Six of the 11 amino acid residues (55 percent) are identical to those in gastrin II. In addition, the intestinal myotropic action of leucosulfakinin is analogous to that of gastrin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19361514	Gastrin II Sulfated		19361-51-4	Price

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