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Levels of Schistosoma Mansoni Circulating Antigen in Chronic Hepatitis C Patients With Different Stages of Liver Fibrosis

Levels of Schistosoma Mansoni Circulating Antigen in Chronic Hepatitis C Patients With Different Stages of Liver Fibrosis

Abdelfattah M Attallah, Mohamed El-Far, Mohamed M Omran, Khaled Farid, Ahmed A Attallah, Dalal Abd-Elaziz, Mohamed S El-Bendary, Ibrahim El-Dosoky, Hisham Ismail

J Immunoassay Immunochem. 2016;37(3):316-30.

PMID: 26745203

Abstract:

The goal of this study was to determine the levels of S. mansoni antigen in different liver fibrosis stages with chronic hepatitis C (CHC) Egyptian patients. A total of 174 CHC patients showing HCV-NS4 antigen and HCV- RNA in their sera were included. S. mansoni antigen was detected in serum using Western blot and ELISA. The levels of interferon-γ (IFN- γ) were determined using ELISA. The 50 kDa S. mansoni antigen discriminated patients infected with S. mansoni from healthy individuals with 0.93 area under curve (AUC), 92% sensitivity, and 97% specificity. The level of S. mansoni antigen (μg/ml) was significantly (P < 0.0001) increased with the progression of liver fibrosis stages (26.9 ± 17.5 in F1, 42.1 ± 25.2 in F2, 49.8 ± 30.3 in F3 and 62.2 ± 26.3 μg/mL in F4 liver cirrhosis), 26.9 ± 17.59 in significant fibrosis (F2-F4); 51.2 ± 27.9 in advanced fibrosis (F3-F4). A significant correlation (r = 0.506; P < 0.0001) was shown between the levels of the S. mansoni antigen and the HCV-NS4 antigen. In conclusion, the presence of S. mansoni antigen in different liver fibrosis stages of CHC patients confirming that concomitant schistosome infection aggravates liver disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414632	Hepatitis C virus NS4 antigen			Price

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