Home
Resources
Publications
Light-activated Gold Nanorod Vesicles With NIR-II Fluorescence and Photoacoustic Imaging Performances for Cancer Theranostics

Light-activated Gold Nanorod Vesicles With NIR-II Fluorescence and Photoacoustic Imaging Performances for Cancer Theranostics

Xiaoguang Ge, Qinrui Fu, Lichao Su, Zhi Li, Wenmin Zhang, Tao Chen, Huanghao Yang, Jibin Song

Theranostics. 2020 Mar 26;10(11):4809-4821.

PMID: 32308751

Abstract:

Fluorescence (FL) and photoacoustic (PA) imaging in the second near infrared window (NIR-II FL and NIR-II PA) hold great promise for biomedical applications because of their non-invasive nature and excellent spatial resolution properties. Methods: We develop a NIR-II PA and NIR-II FL dual-mode imaging gold nanorod vesicles (AuNR Ves) by self-assembly of amphiphilic AuNR coated with light responsive polyprodrug of Ru-complex and PEG, and NIR-II cyanine dye (IR 1061). The AuNR Ves showed strong ligh absorption property and PA imaging performance in the NIR-II windows. Moreover, the NIR-II fluorescence signal of IR 1061 loaded in the AuNR Ve is quenched. Results: The AuNR Ves can release photosensitizer Ru-complex and IR 1061 sequentially triggered by NIR light irradiation, leading to a corresponding NIR-II PA signal decrease and NIR-II FL signal recovery. Meanwhile, Ru-complex can not only serve as a chemotherapeutic drug but also generate singlet oxygen (1O2) under NIR light irradiation. The release of Ru-complex and photodynamic therapy are guided by the responsive variation of NIR-II PA and NIR-II FL signals. Conclusions: The AuNR Ve possessing not only precisely control 1O2/drug release but also the intrinsic ability to monitor therapy process offers a new strategy for the development of smart theranostic nanoplatform.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP155614010	IR-1061		155614-01-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: