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Light-induced Retinal Damage Using Different Light Sources, Protocols and Rat Strains Reveals LED Phototoxicity

Light-induced Retinal Damage Using Different Light Sources, Protocols and Rat Strains Reveals LED Phototoxicity

A Krigel, M Berdugo, E Picard, R Levy-Boukris, I Jaadane, L Jonet, M Dernigoghossian, C Andrieu-Soler, A Torriglia, F Behar-Cohen

Neuroscience. 2016 Dec 17;339:296-307.

PMID: 27751961

Abstract:

To save energy, the European directives from the Eco-design of Energy Using Products (2005/32/CE) have recommended the replacement of incandescent lamps by more economic devices such as Light Emitting Diodes (LEDs). However, the emission spectrum of these devices is enriched in blue radiations, known to be potentially dangerous to the retina. Recent studies showed that light exposure contributes to the onset of early stages of age-related macular degeneration (AMD). Here, we investigate, in albinos and pigmented rats, the effects of different exposure protocols. Twenty-four hours exposure at high luminance was compared to a cyclic (dark/light) exposure at domestic levels for 1week and 1month, using different LEDs (Cold-white, blue and green), as well as fluorocompact bulbs and fluorescent tubes. The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported. It is important to note that the current regulations and standards have been established on the basis of acute light exposure and do not take into account the effects of repeated exposure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1430803216	Green light-emitting spiro-copolymer		1430803-21-6	Price

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