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Linalool Hydroperoxides

Anton de Groot

Dermatitis. Jul/Aug 2019;30(4):243-246.

PMID: 31313746

Abstract:

Linalool is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to linalool was considered rare because positive patch tests to it were infrequently observed. In recent years, however, it has been demonstrated that exposure of linalool to oxygen (air) results in formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound. By routine testing of patients suspected of having contact dermatitis with hydroperoxides of linalool, high frequencies of positive reactions were found, indicating these chemicals are important fragrance allergens. It should be realized, however, that a number of "positive" reactions may well be false-positive, irritant responses.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP126910 (−)-Linalool (−)-Linalool 126-91-0 Price
AP78706 Linalool Linalool 78-70-6 Price
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