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Lipocalin 2 Produces Insulin Resistance and Can Be Upregulated by Glucocorticoids in Human Adipose Tissue

Lipocalin 2 Produces Insulin Resistance and Can Be Upregulated by Glucocorticoids in Human Adipose Tissue

Prasad G Kamble, Maria J Pereira, Cherno O Sidibeh, Sam Amini, Magnus Sundbom, Joey Lau Börjesson, Jan W Eriksson

Mol Cell Endocrinol. 2016 May 15;427:124-32.

PMID: 26973291

Abstract:

The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPARγ and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42412472	Lipocalin-2 human			Price

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