Home
Resources
Publications
Lipopolysaccharide-specific but Not Anti-Flagellar Immunoglobulin A Monoclonal Antibodies Prevent Salmonella Enterica Serotype Enteritidis Invasion and Replication Within HEp-2 Cell Monolayers

Lipopolysaccharide-specific but Not Anti-Flagellar Immunoglobulin A Monoclonal Antibodies Prevent Salmonella Enterica Serotype Enteritidis Invasion and Replication Within HEp-2 Cell Monolayers

Ianko D Iankov, Dragomir P Petrov, Ivan V Mladenov, Iana H Haralambieva, Ivan G Mitov

Infect Immun. 2002 Mar;70(3):1615-8.

PMID: 11854252

Abstract:

The protective potential of immunoglobulin A (IgA) monoclonal antibodies (MAbs) directed against O and H antigens of Salmonella enterica serotype Enteritidis to prevent bacterial adhesion to and invasion of HEp-2 cells was evaluated. Although anti-flagellar IgA MAbs showed strong agglutinating capacities, they did not protect cell monolayers. In contrast, IgA MAbs specific for the O:9 epitope of Salmonella lipopolysaccharide antigen alone prevented S. enterica serotype Enteritidis entry and replication within HEp-2 cells, and the protection was not mediated by direct binding of antibodies to bacterial adhesins or by agglutination of microorganisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741386	Lipopolysaccharides from Salmonella enterica serotype enteritidis			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: