Home
Resources
Publications
Lipsosomal Amphotericin B: A Review of Its Properties, Function, and Use for Treatment of Cutaneous Leishmaniasis

Lipsosomal Amphotericin B: A Review of Its Properties, Function, and Use for Treatment of Cutaneous Leishmaniasis

Mohammad Reza Shirzadi

Res Rep Trop Med. 2019 Apr 26;10:11-18.

PMID: 31118866

Abstract:

The genus Leishmania includes a number of protozoan parasites that cause a wide range of infections named leishmaniasis. Leishmaniasis may be appear in three clinical forms - cutaneous (CL), visceral, and mucocutaneous (MCL) - with variation in their presentation and severity: diffuse CL and post-kala-azar dermal leishmaniasis). The prevalent signs of CL are nonhealing ulcers on exposed skin, but infected patients may have other dermatologic symptoms. In the 1960s, amphotericin B deoxycholate was introduced as a second-line therapy for CL and MCL. However, widespread administration of the agent was prevented, due to its renal and systemic toxicity, high price, and obstacles to intravenous use in leishmaniasis-endemic regions. Amphotericin B binds to ergosterol in the photogenic cell membranes and causes changes in membrane permeability, leakage of ions, and finally cell death. Compared to amphotericin B deoxycholate, a higher dose of liposomal amphotericin B should be administered to show the treatment effect. A high percentage of liposomal amphotericin B is "fastened" in the liposome and not biologically effective. Amphotericin B deoxycholate has some toxic effects, and liposomal amphotericin B is meaningfully less toxic compared to it. Treatment options for CL are limited, due to variation in species causing CL and pharmacokinetic issues. Amphotericin B is effective against some particular forms of CL.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1397893-A	Amphotericin B		1397-89-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: