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Liquid Chromatographic Determination of Methscopolamine Bromide in Various Veterinary Formulations

P A Hartman

J Assoc Off Anal Chem. 1979 Sep;62(5):1099-106.

PMID: 528455

Abstract:

A reverse phase paired ion liquid chromatographic procedure is described for determining methscopolamine bromide (Pamine) in the presence of neomycin sulfate in 5 veterinary formulations (Biosol M). Methscopolamine bromide is separated from neomycin sulfate and other formulation excipients by extraction into ethanol. The sample preparations are then concentrated and dissolved in water before chromatography. Recovery of methscopolamine bromide added to 5 placebo formulations ranged from 99.7 to 100.7%, with relative standard deviations of less than 2%. Specificity of the method with regard to potential degradation products is demonstrated.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP155419-A Methscopolamine bromide Methscopolamine bromide 155-41-9 Price
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