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Liquid Chromatographic Method for Perphenazine and Its Sulfoxide in Pharmaceutical Dosage Forms for Determination of Stability

N Beaulieu, E G Lovering

J Assoc Off Anal Chem. Jan-Feb 1986;69(1):167-9.

PMID: 3949688

Abstract:

A liquid chromatographic method is described for determination of perphenazine and perphenazine sulfoxide in representative dosage forms. Sulfoxide levels were nondetectable or less than 1% in tablets and in an injectable product. Sulfoxide levels increase with time in some syrup formulations and may be as high as 11% in syrup formulations before their expiration date.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP10078258 Perphenazine sulfoxide Perphenazine sulfoxide 10078-25-8 Price
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