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Loading and Release of Fluorescent Dye From Layer-By-Layer Film-Coated Magnetic Particles in Response to Hydrogen Peroxide

Loading and Release of Fluorescent Dye From Layer-By-Layer Film-Coated Magnetic Particles in Response to Hydrogen Peroxide

Katsuhiko Sato, Eiichi Abe, Mao Takahashi, Jun-ichi Anzai

J Colloid Interface Sci. 2014 Oct 15;432:92-7.

PMID: 25084230

Abstract:

Polymer-coated magnetic particles (MPs) were prepared to study the binding of fluorescence dye on the surface and its H2O2-induced release. For this goal, multilayer films were prepared by layer-by-layer deposition of shikimic acid-appended poly(allylamine hydrochloride) (SA-PAH) and poly(styrenesulfonate) (PSS) on the surface of MPs. 3-(Dansylamino)phenylboronic acid (DPBA) was loaded on the MPs through boronate ester bonding between SA-PAH and DPBA. DPBA was released from the MPs in response to H2O2 as a result of breakage of the boronate ester bond by an oxidative reaction with H2O2. DPBA release was dependent on the H2O2 concentration. For example, 65% and 93% of the DPBA was released from (SA-PAH/PSS)4SA-PAH film-coated MPs in 30min after the addition of 0.1 and 0.5mM H2O2, respectively. In addition, the multilayer film-coated MPs were further modified by using glucose oxidase (GOx) to develop glucose-induced release systems. GOx-modified MPs released DPBA in response to 0.1mM d-glucose as a result of H2O2 generation through a GOx-catalyzed oxidation reaction of d-glucose. The results suggest a potential use of the multilayer film-coated MPs in the development of H2O2- and/or glucose-sensitive drug delivery systems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP75806949	3-(Dansylamino)phenylboronic acid		75806-94-9	Price

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