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Local Sustained-Release Delivery Systems of the Antibiofilm Agent thiazolidinedione-8 for Prevention of Catheter-Associated Urinary Tract Infections

Local Sustained-Release Delivery Systems of the Antibiofilm Agent thiazolidinedione-8 for Prevention of Catheter-Associated Urinary Tract Infections

Julia Shenderovich, Mark Feldman, David Kirmayer, Abed Al-Quntar, Doron Steinberg, Eran Lavy, Michael Friedman

Int J Pharm. 2015 May 15;485(1-2):164-70.

PMID: 25769292

Abstract:

Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit(®) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33434241-A	Ammonio methacrylate copolymer type A		33434-24-1	Price

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