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Local VEGF Inhibition Prevents Ovarian Alterations Associated With Ovarian Hyperstimulation Syndrome

Local VEGF Inhibition Prevents Ovarian Alterations Associated With Ovarian Hyperstimulation Syndrome

Leopoldina Scotti, Dalhia Abramovich, Natalia Pascuali, Griselda Irusta, Gabriela Meresman, Marta Tesone, Fernanda Parborell

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:392-401.

PMID: 25151950

Abstract:

The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413782	VEGF Receptor-1 (Flt-1)/Fc Chimera human			Price
IAR42413783	VEGF Receptor-1 (Flt-1)/Fc Chimera from mouse			Price

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