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Localization of Antimicrobial Peptides Human Beta-Defensins in Minor Salivary Glands With Sjögren's Syndrome

Localization of Antimicrobial Peptides Human Beta-Defensins in Minor Salivary Glands With Sjögren's Syndrome

Yoshihiro Kaneda, Tomoichiro Yamaai, Nobuyoshi Mizukawa, Hitoshi Nagatsuka, Eiki Yamachika, Mehmet Gunduz, Koichi Sawaki, Yuji Yamanishi, Masakazu Matsubara, Naoki Katase, Shin Takagi

Eur J Oral Sci. 2009 Oct;117(5):506-10.

PMID: 19758245

Abstract:

Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human beta-defensin-1, human beta-defensin-2, and human beta-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human beta-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human beta-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human beta-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human beta-defensin-2 was greater than the reduction in expression of human beta-defensin-1. The aforementioned result suggests that the reduction in expression of human beta-defensin-2 may occur earlier than the reduction in expression of human beta-defensin-1, which may lead to a greater decrease in human beta-defensin-2 than in human beta-defensin-1 during disease progression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414765	β-Defensin 1 human			Price

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