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Long-term Efficacy Data for daylight-PDT

Long-term Efficacy Data for daylight-PDT

Carlota Gutiérrez García-Rodrigo, Cristina Pellegrini, Antonella Piccioni, Matteo Maini, Maria Concetta Fargnoli

G Ital Dermatol Venereol. 2018 Dec;153(6):800-805.

PMID: 29683285

Abstract:

Introduction:
Conventional photodynamic therapy (c-PDT) is an established successful treatment for non-melanoma skin cancers (NMSC). Daylight PDT (DL-PDT) was introduced to overcome the main inconveniencies associated with c-PDT such as pain during illumination and long clinic visits. DL-PDT was shown to have similar short-term efficacy to c-PDT for the treatment of mild/moderate actinic keratosis (AKs) but it is associated with better tolerability. Since AKs tend to regress and reoccur over time, data on long-term efficacy of DL-PDT become crucial.
Evidence acquisition:
We performed a systematic review search up to February 2018 of available studies on DL-PDT long-term efficacy using the MEDLINE database and made a manual search of selected references.
Evidence synthesis:
Most current studies on DL-PDT have limited follow-up periods of 3 to 6 months. Only 2 randomized, intra-individual studies provided efficacy data on AK treatment at 12 month-follow-up and supported the long-term efficacy of this novel treatment modality showing a low recurrence rate, varying from 8.7% to 13%. Current evidences for other NMSCs are limited and efficacy seems to be not as good as for AK.
Conclusions:
DL-PDT is a very promising treatment for mild to moderate AKs of the face and scalp. Efficacy outcomes of DL-PDT are similar to those of c-PDT in the short-term. Additional studies are required to increase our knowledge on DL-PDT long-term efficacy, as limited data are currently available.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14085337	CPDT		14085-33-7	Price

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