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Low Circulating IGF-I Bioactivity Is Associated With Human Longevity: Findings in Centenarians' Offspring

Giovanni Vitale, Michael P Brugts, Giulia Ogliari, Davide Castaldi, Letizia M Fatti, Aimee J Varewijck, Steven W Lamberts, Daniela Monti, Laura Bucci, Elisa Cevenini, Francesco Cavagnini, Claudio Franceschi, etc.

Aging (Albany NY). 2012 Sep;4(9):580-9.

PMID: 22983440

Abstract:

Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p〈0.01), total IGF-I (p〈0.01) and the IGF-I/IGFBP-3 molar ratio (p〈0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity.
In conclusion:
1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413310 IGF-I human IGF-I human Price
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