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Luteal Changes After Treatment With Sub-Luteolytic Doses of Prostaglandin (Cloprostenol Sodium) in Cattle

Luteal Changes After Treatment With Sub-Luteolytic Doses of Prostaglandin (Cloprostenol Sodium) in Cattle

Eduardo Trevisol, Jair Camargo Ferreira, Camila Louise Ackermann, Flavia Caroline Destro, Wolff Camargo Marques Filho, Aline Souza Carmagos, Marcos Vinicius Biehl, Jackson Barros do Amaral, José Carlos de Figueiredo Pantoja, etc.

Anim Reprod Sci. 2015 Feb;153:8-12.

PMID: 25578505

Abstract:

This study characterizes the physiological and morphological changes related to partial luteolysis in bovine corpus luteum (CL) after challenges with sub-doses of cloprostenol sodium on Day 6 (D6) of the estrous cycle. Cows (n = 12/treatment) were treated as follows: Control (2 mL, saline, i.m.); 2XPGF (two treatments i.m. 500 μg of cloprostenol sodium 2 h apart) and 1/6PGF (83.3 μg of cloprostenol sodium, i.m., once). Plasma progesterone (P4) concentration, CL volume and blood flow were measured immediately before the treatments, then every 8 h (h) for 48 h. In the Control, P4 concentrations were higher at 48 h than at 0 h. P4 decreased 8h after 2XPGF treatment (P < 0.05), and remained low until the end of the trial. P4 decreased in 1/6PGF between 8 and 16 h (P < 0.05), then began to rebound at 24 h. Luteal volume was higher in Controls at 48 h than at 0 h. Under 1/6PGF, luteal volume decreased at 24 h (P < 0.05) and began to rebound at 32 h. Luteal volume and blood flow were reduced starting at 24 and 32 h, respectively, after 2XPGF treatment (P < 0.05). In this study, we were able to describe the partial luteolysis phenomenon, induced by a treatment of a D6CL with cloprostenol sub-dose.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP55028723-A	Cloprostenol sodium		55028-72-3 (anhydrous)	Price

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