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Lycorine Hydrochloride Inhibits Metastatic Melanoma Cell-Dominant Vasculogenic Mimicry

Lycorine Hydrochloride Inhibits Metastatic Melanoma Cell-Dominant Vasculogenic Mimicry

Ruifang Liu, Zhifei Cao, Jian Tu, Yanyan Pan, Bingxue Shang, Gaochuan Zhang, Meimei Bao, Shasha Zhang, Ping Yang, Quansheng Zhou

Pigment Cell Melanoma Res. 2012 Sep;25(5):630-8.

PMID: 22781316

Abstract:

Melanoma cells actively participate in tumor angiogenesis and vasculogenic mimicry. However, anti-angiogenic therapy in patients with melanoma has not shown a significant survival gain. Thus, new anti-melanoma angiogenic and vasculogenic drugs are highly desired. Using the metastatic melanoma cell line C8161 as a model, we explored melanoma vasculogenic inhibitors and found that lycorine hydrochloride (LH) effectively suppressed C8161 cell-dominant formation of capillary-like tubes in vitro and generation of tumor blood vessels in vivo with low toxicity. Mechanistic studies revealed that LH markedly hindered expression of VE-cadherin in C8161 cells, but did not affect expression of six other important angiogenic and vasculogenic genes. Luciferase assays showed that LH significantly impeded promoter activity of the VE-cadherin gene in a dose-dependent manner. Together, these data suggest that LH inhibits melanoma C8161 cell-dominant vasculogenic mimicry by reducing VE-cadherin gene expression and diminishing cell surface exposure of the protein.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2188683	Lycorine hydrochloride		2188-68-3	Price

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