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Lysophosphatidylcholine Synthesis With Candida Antarctica Lipase B (Novozym 435)

Lysophosphatidylcholine Synthesis With Candida Antarctica Lipase B (Novozym 435)

C Virto, P Adlercreutz

Enzyme Microb Technol. 2000 May 1;26(8):630-635.

PMID: 10793211

Abstract:

Immobilized lipase from Candida antarctica lipase B (Novozym 435) was effective in the synthesis of lysophosphatidylcholine (LPC). The transesterification of L-alpha-glycerophosphorylcholine (GPC) and vinyl laurate was carried out in a solvent free system or in the presence of 50% (v/v) t95%) were easily achieved. The lipase was selective for the sn10 times). High purity products could be produced by a decrease of the reaction temperature to induce precipitation of the product. The temperature needed depended on the fatty acid chain length. Thus, only lysophosphatidylcholine was produced with palmitic acid vinyl ester at 45 degrees C, whereas for the vinyl esters of lauric acid, capric acid, and caprylic acid, a lower reaction temperature (25 degrees C) was necessary to obtain solely the lysophospholipid products.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42412154	L-α-Glycerophosphorylcholine			Price

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