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Lysosomal Generation of Amyloid Beta Protein Species in Transgenic Mice

Lysosomal Generation of Amyloid Beta Protein Species in Transgenic Mice

T Kawarabayashi, Y Igeta, M Sato, A Sasaki, E Matsubara, M Kanai, Y Tomidokoro, K Ishiguro, K Okamoto, S Hirai, M Shoji

Brain Res. 1997 Aug 15;765(2):343-8.

PMID: 9313910

Abstract:

Soluble amyloid beta protein (A beta)1-40 and highly amyloidogenic A beta 1-42/43 were immunocytochemically labeled in lysosomes of acinar cells and macrophages in the pancreas of transgenic mice systemically expressing a C-terminal fragment of the A beta precursor. A beta 1-42/43 and long A beta species extending their C-termini were detected in the detergent-insoluble fraction. Immunoreactivity of cathepsin D was markedly increased in lysosomes filled with A beta fibrils. These findings indicated that A beta 1-40, A beta 1-42, A beta 1-43 and longer A beta species were generated in the lysosomes of the transgenic pancreas, and suggested that the activation of cathepsin D, a candidate gamma-secretase, leads to acceleration of A beta amyloid formation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP134500804	Amyloid β-Protein Fragment 1-43		134500-80-4	Price

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