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m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats

m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats

Said Salama Moselhy, Syed Shoeb Razvi, Fawzia A ALshibili, Abudukadeer Kuerban, Mohammed Nihal Hasan, Khadijah Saeed Balamash, Etimad A Huwait, Wesam H Abdulaal, Maryam A Al-Ghamdi, Taha A Kumosani, Khalid Omar Abulnaja, etc.

J Pestic Sci. 2018 Aug 20;43(3):180-185.

PMID: 30363123

Abstract:

In this study, we investigated the inhibitory effects of m-coumaric acid on the glycosylation of proteins in the retinas of diabetic rats. Male rats were divided into two main groups, Group I (normal control) and Group II (diabetic); Group II was further divided into four subgroups: Group IIa (diabetic control), Group IIb (diabetic rats were given m-coumaric acid orally [150 mg/kg, body weight (bw)/day]), Group IIc (diabetic rats were given HCA m-coumaric acid orally [300 mg/kg bw/day]), and Group IId (diabetic rats were given insulin [10 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, and the data obtained suggested that m-coumaric acid reduced glucose and glycated hemoglobin levels, which further decreased the formation of glucose-derived advanced glycation end products. Hence, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. In conclusion, m-coumaric acid could be a potential candidate to prevent the onset and progression of retinopathy in diabetic patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP588307	m-Coumaric acid		588-30-7	Price

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