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Magnetic, Fluorescent, and Thermo-Responsive Fe(3)O(4)/rare Earth Incorporated poly(St-NIPAM) Core-Shell Colloidal Nanoparticles in Multimodal optical/magnetic Resonance Imaging Probes

Magnetic, Fluorescent, and Thermo-Responsive Fe(3)O(4)/rare Earth Incorporated poly(St-NIPAM) Core-Shell Colloidal Nanoparticles in Multimodal optical/magnetic Resonance Imaging Probes

Haie Zhu, Juan Tao, Wenhao Wang, Yingjie Zhou, Penghui Li, Zheng Li, Kai Yan, Shuilin Wu, Kelvin W K Yeung, Zushun Xu, Haibo Xu, Paul K Chu

Biomaterials. 2013 Mar;34(9):2296-306.

PMID: 23274069

Abstract:

Multifunctional colloidal nanoparticles which exhibit fluorescence, superparamagnetism, and thermosensitivity are produced by two step seed emulsifier-free emulsion polymerization in the presence of oleic acid (OA) and sodium undecylenate (NaUA) modified Fe(3)O(4) nanoparticles. In the first step, St and NIPAM polymerize the NaUA on the surface of Fe(3)O(4) nanoparticles to form Fe(3)O(4)/poly(St-NIPAM) nanoparticles which act as seeds for the polymerization of Eu(AA)(3)Phen with the remaining St and NIPAM in the second step to form an outer fluorescent layer. The core-shell composite nanoparticles show reversible dimensional changes in response to external temperature stimuli. Fluorescence spectra acquired from the composites exhibit characteristic emission peaks of Eu(3+) at 594 and 619 nm and vivid red luminescence can be observed by 2-photon confocal scanning laser microscopy (CLSM). In vitro cytotoxicity tests based on the MTT assay demonstrate good cytocompatibility and the composites also possess paramagnetic properties with a maximum saturation magnetization of 6.45 emu/g and high transverse relaxivity rates (r(2)) of 411.78 mM(-1) s(-1). In vivo magnetic resonance imaging (MRI) studies show significant liver and spleen contrast with relative signal intensity reduction of about 86% 10 min after intravenous injection of the composites. These intriguing properties suggest that these nanocarriers have large clinical potential as multimodal optical/MRI probes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247272	Sodium undecylenate			Price

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