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Magnetic Multi-Walled Carbon Nanotube Poly(styrene-Co-Divinylbenzene) for Propranolol Extraction and Separation by Capillary Electrophoresis

Magnetic Multi-Walled Carbon Nanotube Poly(styrene-Co-Divinylbenzene) for Propranolol Extraction and Separation by Capillary Electrophoresis

Carlos Adelantado, Khaled Murtada, Ángel Ríos, Mohammed Zougagh

Bioanalysis. 2018 Aug 1;10(15):1193-1205.

PMID: 30033745

Abstract:

Aim:
The preparation of magnetic multi-walled carbon nanotube poly(styrene-co-divinylbenzene) for propranolol magnetic solid-phase extraction is described.
Materials & methods:
A study comparing propranolol adsorption and desorption was performed with only magnetic multi-walled carbon nanotubes, and different poly(styrene-co-divinylbenzene) with and without magnetic multi-walled carbon nanotubes. Enantiomeric separation of propranolol took place by cyclodextrin-modified capillary electrophoresis and the method was validated in spiked human urine samples.
Results:
Recovery values raised when styrene/divinylbenzene millimoles ratio was 19.57:15.80. Enrichment factors increased up to approximately 100, detection limits were 13.8 and 10.5 ng ml-1 for R- and S-propranolol respectively, quantitation limits were 46.0 and 34.8 ng ml-1 for R- and S-propranolol respectively, recoveries from spiked samples ranged from 90.9 to 109.0%, and relative standard deviations were <6.3%.
Conclusion:
This methodology was proven to be more effective than classical solid-phase extraction strategies and may be applied to other kind of biological samples.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1321740	Divinylbenzene		1321-74-0	Price
AP308068566-A	Carbon nanotube, multi-walled		308068-56-6	Price

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