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Malignant Hyperthermia

Malignant Hyperthermia

Harleen Kaur, Nakul Katyal, Anudeep Yelam, Keerthana Kumar, Hirsch Srivastava, Raghav Govindarajan

Mo Med. Mar-Apr 2019;116(2):154-159.

PMID: 31040503

Abstract:

Malignant Hyperthermia (MH) is a life-threatening pharmacogenetic disorder which results from exposure to volatile anesthetic agents and depolarizing muscle relaxants. It manifests as a hypermetabolic response resulting in tachycardia, tachypnea, hyperthermia, hypercapnia, acidosis, muscle rigidity and rhabdomyolysis. An increase in the end-tidal carbon dioxide is one of the earliest diagnostic signs. Dantrolene sodium is effective in the management of MH, and should be available whenever general anesthesia is administered. This review also aims to highlight the genetics and pathology of MH, along with its association with various inherited myopathy syndromes like central core disease, multi-mini core disease, Native-American myopathy, and King-Denborough syndrome.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24868200	Dantrolene sodium		24868-20-0	Price

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