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Mam33 Promotes Cytochrome C Oxidase Subunit I Translation in Saccharomyces Cerevisiae Mitochondria

Mam33 Promotes Cytochrome C Oxidase Subunit I Translation in Saccharomyces Cerevisiae Mitochondria

Gabrielle A Roloff, Michael F Henry

Mol Biol Cell. 2015 Aug 15;26(16):2885-94.

PMID: 26108620

Abstract:

Three mitochondrial DNA-encoded proteins, Cox1, Cox2, and Cox3, comprise the core of the cytochrome c oxidase complex. Gene-specific translational activators ensure that these respiratory chain subunits are synthesized at the correct location and in stoichiometric ratios to prevent unassembled protein products from generating free oxygen radicals. In the yeast Saccharomyces cerevisiae, the nuclear-encoded proteins Mss51 and Pet309 specifically activate mitochondrial translation of the largest subunit, Cox1. Here we report that Mam33 is a third COX1 translational activator in yeast mitochondria. Mam33 is required for cells to adapt efficiently from fermentation to respiration. In the absence of Mam33, Cox1 translation is impaired, and cells poorly adapt to respiratory conditions because they lack basal fermentative levels of Cox1.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9007436-B	Cytochrome c from Saccharomyces cerevisiae		9007-43-6	Price

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