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Mammalian neurotrophin-4: Structure, Chromosomal Localization, Tissue Distribution, and Receptor Specificity

Mammalian neurotrophin-4: Structure, Chromosomal Localization, Tissue Distribution, and Receptor Specificity

N Y Ip, C F Ibáñez, S H Nye, J McClain, P F Jones, D R Gies, L Belluscio, M M Le Beau, R Espinosa 3rd, S P Squinto

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3060-4.

PMID: 1313578

Abstract:

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248822	NT-4 human			Price

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