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Mapping the landscape of human dopamine D2/3 receptors with [ 11 C]raclopride

Mapping the landscape of human dopamine D2/3 receptors with [ 11 C]raclopride

Goran Papenberg, Lars Jonasson, Nina Karalija, Jarkko Johansson, Ylva Köhncke, Alireza Salami, Micael Andersson, Jan Axelsson, Anders Wåhlin, Katrine Riklund, Ulman Lindenberger, Martin Lövdén, Lars Nyberg, etc.

Brain Struct Funct. 2019 Nov;224(8):2871-2882.

PMID: 31444615

Abstract:

The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BPND in the extrastriatal regions with [11C]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [11C]raclopride across the human brain in a large sample (N = 176; age range 64-68 years). Structural equation modeling revealed that D2/3DR availability can be organized according to anatomical (nigrostriatal, mesolimbic, mesocortical) and functional (limbic, associative, sensorimotor) dopamine pathways. D2/3DR availability in corticolimbic functional subdivisions showed differential associations to corresponding striatal subdivisions, extending animal and pharmacological work. Our findings provide evidence on the dimensionality and organization of [11C]raclopride D2/3DR availability in the living human brain that conforms to known dopaminergic pathways.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP207507220	Iodomethane-13C,d2		207507-22-0	Price
IAR4244651	17-Phenyl-tri-norprostaglandin D2			Price

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