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Marine Natural Products. XXIII. Three New Cytotoxic Dimeric Macrolides, Swinholides B and C and Isoswinholide A, Congeners of Swinholide A, From the Okinawan Marine Sponge Theonella Swinhoei

Marine Natural Products. XXIII. Three New Cytotoxic Dimeric Macrolides, Swinholides B and C and Isoswinholide A, Congeners of Swinholide A, From the Okinawan Marine Sponge Theonella Swinhoei

M Kobayashi, J Tanaka, T Katori, I Kitagawa

Chem Pharm Bull (Tokyo). 1990 Nov;38(11):2960-6.

PMID: 2085878

Abstract:

Following the characterization of swinholide A (1), the major cytotoxic dimeric macrolide, three new congeneric dimeric macrolides, named swinholide B (2), swinholide C (3) and isoswinholide A (10), have been isolated from the Okinawan marine sponge Theonella swinhoei. The structures of these dimeric macrolides have been elucidated on the basis of chemical and physicochemical evidence. These dimeric macrolides were shown to exhibit potent cytotoxicities toward KB cell lines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413786	Swinholide A from Theonella swinhoei			Price

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