Home
Resources
Publications
Marine Natural Products. XXXI. Structure-activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, From the Okinawan Marine Sponge Theonella Swinhoei, and Its Isomers

Marine Natural Products. XXXI. Structure-activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, From the Okinawan Marine Sponge Theonella Swinhoei, and Its Isomers

M Kobayashi, K Kawazoe, T Okamoto, T Sasaki, I Kitagawa

Chem Pharm Bull (Tokyo). 1994 Jan;42(1):19-26.

PMID: 8124763

Abstract:

Acidic treatment of swinholide A (1), which was characterized as the major cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei, provided several isomeric macrolides having different size of the dilactone ring structure. From the structure-activity correlation viewpoint, the in vitro cytotoxicities and in vivo antitumor activities of these dimeric macrolides, together with two monomeric macrolides which were synthesized from 1, have been examined.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413786	Swinholide A from Theonella swinhoei			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: