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Mass Fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in Human Cerebrospinal Fluid

Mass Fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in Human Cerebrospinal Fluid

H C Curtius, M Wolfensberger, U Redweik, W Leimbacher, R A Maibach, W Isler

J Chromatogr. 1975 Oct 29;112:523-31.

PMID: 1184685

Abstract:

A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass fragmentography and pentafluoropriopionyl derivatives is described. 5-HTOL and 5-MTOL were determined in human CSF of three patients with leukaemia and from nine patients with neurological disorders. The concentration of free 5-HOT in CSF was in the range of 0.1-33 ng/ml and that of 5-MTOL was 0.3-13.9 ng/ml. For the first time the presence of these compounds in human material has been shown. The concentration of these two alcohols in CSF is markedly lower than the concentration of 5-hydroxyindoleacetic acid. These results suggest that human cerebral 5-hydroxytryptamine is preferentially metabolized to 5-HTOL-hydroxyindoleacetic acid rather than to 5-HTOL and 5-MTOL.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP712094	5-Methoxytryptophol		712-09-4	Price

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