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Mast Cell Production and Response to IL-4 and IL-13

Mast Cell Production and Response to IL-4 and IL-13

Jamie J A McLeod, Bianca Baker, John J Ryan

Cytokine. 2015 Sep;75(1):57-61.

PMID: 26088754

Abstract:

IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4Rα, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413411	IL-4 from mouse			Price

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