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Maternal and Neonatal Wellbeing During Elective C-section Induced With a Combination of Propofol and Dexmedetomidine: How Effective Is the Placental Barrier in Dogs?

Maternal and Neonatal Wellbeing During Elective C-section Induced With a Combination of Propofol and Dexmedetomidine: How Effective Is the Placental Barrier in Dogs?

Debora Groppetti, Federica Di Cesare, Alessandro Pecile, Petra Cagnardi, Roberta Merlanti, Elisa S D'Urso, Daniela Gioeni, Patrizia Boracchi, Giuliano Ravasio

Theriogenology. 2019 Apr 15;129:90-98.

PMID: 30826722

Abstract:

Anaesthetics administered during C-section (CS) can cross the placenta and the foetal blood-brain barrier contributing to distress up to neonatal mortality. Therefore, to prevent neonatal risks, sedatives and analgesics are not commonly administered to the bitch until all pups are delivered. This study aims to evaluate the effect of a new anaesthetic and analgesic protocol for elective CS in dogs, focused on both maternal and neonatal wellbeing. General anaesthesia was induced by a combination of propofol (PPF) and dexmedetomidine (DEX) and maintained with isoflurane. DEX was added to PPF in order to provide analgesia and to reduce PPF dose. Propofol and DEX concentrations in maternal blood, amniotic fluid, and placenta were correlated to maternal and neonatal parameters. Maternal pain score was assessed with Glasgow Composite Measure Pain Scale short-form. Nine healthy purebred dogs scheduled for elective CS delivered 54 pups. The 77.8% of pups were vigorous at birth and assigned to the highest Apgar score (AS). The lowest AS was recorded in pups from mothers receiving additional doses of PPF (p < 0.001). Apgar scores improved with the increase in time between induction and pups' extraction, starting from 30 min after induction (p < 0.01). This study could contribute to clarify the controversy about the optimal extraction's time of pups after induction i.e. the best time between PPF administration and birth. No bitch showed post-operative pain or required additional analgesic doses based on their pain score. Maternal blood PPF and DEX, as well as placental PPF concentrations, decreased over time (p < 0.01). Conversely, placental DEX was fair uniformly detected in littermate pups. Both PPF and DEX were not detectable in amniotic fluid. Placenta resulted an effective barrier against foetal DEX exposure, making this protocol safe, analgesic and advisable for elective CS in dogs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP911397278	PPF		911397-27-8	Price

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