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Matrix metalloproteinase-9: Many Shades of Function in Cardiovascular Disease

Matrix metalloproteinase-9: Many Shades of Function in Cardiovascular Disease

Andriy Yabluchanskiy, Yonggang Ma, Rugmani Padmanabhan Iyer, Michael E Hall, Merry L Lindsey

Physiology (Bethesda). 2013 Nov;28(6):391-403.

PMID: 24186934

Abstract:

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP959417857	9,9-Dioctyl-9H-fluoren-2-amine		959417-85-7	Price

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