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May Nesfatin-1 Be a Biomarker in Acute Mesenteric Ischemia?

May Nesfatin-1 Be a Biomarker in Acute Mesenteric Ischemia?

Cihad Tatar, Fatih Alper Ahlatci, Ufuk Oguz Idiz, Ali Emre Nayci, Said Incir, Orhan Agcaoglu, Cemile Idiz, Emre Balik

J Coll Physicians Surg Pak. 2019 Oct;29(10):928-931.

PMID: 31564263

Abstract:

Objective:
To investigate the diagnostic value of nesfatin-1 in cases of intestinal ischemia and ischemia/reperfusion.
Study design:
An experimental study.
Place and duration of study:
The Experimental Animals Laboratory of Bezmialem University, in June 2018.
Methodology:
Twenty-one healthy male Sprague Dawley rats were randomly divided into three groups of 7 rats each. In group 1: 1-hour intestinal ischemia followed by 5-hour reperfusion was performed. In group 2: rats were subjected to 6-hour intestinal ischemia. In group 3: rats underwent laparotomy and closure without performing any further procedure. Changes in leukocyte count, amylase, blood sugar, LDH, SGOT, CRP, and nesfatin-1 levels were determined. For histopathological examination, a small intestinal sample was taken and preserved in 10% formaldehyde.
Results:
Nesfatin-1 value in group 2 was significantly higher than that in group 1 and group 3 (p=0.005, and p <0.001 respectively). Nesfatin-1 value in group 1 was significantly higher than that in group 3. A significant (r = 0.864/p <0.001) positive correlation was observed between nesfatin-1 value and pathology score. The pathology score of group 2 was significantly higher than that of group 1 and group 3 (p <0.001).
Conclusion:
Serum nesfatin-1 can be a biomarker in acute mesenteric ischemia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413033	Nesfatin-1			Price

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